Effect of selected binders and disintegrants on the dissolution rate of terbinafine hydrochloride from tablets

Authors: P. Arnaudova, V. Dilova,

Abstract

Terbinafin hydrochloride is slightly soluble in water, therefore its oral absorption is limited by the dissolution rate. Poor aqueous solubility of the drug gives rise to difficulties in the formulation of dosage forms and may lead to variable dissolution rate and bioavailability. All samples of tablets containing 250 mg terbinafine were prepared by conventional wet granulation method. Varius type of disintegrants and binders as sodium starch glycolate (Primojel, Avebe Veendan); croscarmellose sodium (Vivasol, JRS); pregelatinized starch (Starch 1500, Colorcon); polyvinylpyrolidone (PVP, K-25); hydroxypropylmethylcellulose; hydroxypropylcellulose; microcrystalline cellulose (Vivapur 200, JRS) were used to prepared some series of tablets. HPMC as binder and croscarmellose sodium and pregelatinized starch as disintegrants showed higher dissolution rate

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