Validation of HPLC method for determination of HMG Co-A reductase inhibitors

Authors: B. Tsvetkova, G. Petrova, I. Pencheva, M. Manova, P. Peikov,

Summary. The goal of the present study is an adaptation and validation of the Pharmacopoeia HPLC method for evaluation of HMG-Co A reductase inhibitors. In adaptation, mobile phase and chromatographic column are modified. The analytical procedure is validated with respect to specificity, linearity, precision, accuracy, robustness and LOD and LOQ. The proposed RP-LC method can be applied for the routine analysis of commercially available formulations of simvastatin and lovastatin.

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