Abstract: Indometacin incorporation in nanoparticles can reduce the side effects of the drug on the gastrointestinal mucosa. In the present study, indometacin was loaded into poly(lactide-co-glicolide) nanoparticles by simple solvent evaporation method. Nanoparticles possessed average diameter of 500nm and low polydispersity index (0.2). Variation of the initial ratio between the drug and polymer influenced drug loading degree. The results showed that the increase of the drug concentration resulted in higher loading. The in vitro release profiles in acid and phosphate buffers showed biphasic manner – initial rapid indometacin release followed by slower release for a longer period. The initial burst effect was decreased by coating of nanoparticles with carbopol. In conclusion, the coating of indometacin loaded nanoparticles could be considered appropriate approach for the development of nanosized delivery system with reduced burst release and eventually reduced side effects.