Social and health importance and analytical characteristics of Losartan

personАвтори: S. Ognjanov, St. Pankova


The aim of current study is to summarize and comprise the different developed methods for determination of angiotensin receptor blocker Losartan Роtassium alone and in combination with calcuim antagonists, ACE – inhibitors and diuretics (Hydrochlorothiazide) in dosage pharmaceutical preparations (tablets, capsules) and in biological materials (plasma, urine). The reported techniques for the determination of Losartan Potassium include: 1) high performance liquid chromatography (HPLC) with UV –  detection (tablets, capsules, plasma, urine); 2) HPLC with fluorescence detection (plasma, urine); 3) HPLC with mas detection (tablets, plasma); 4) supercritical fluid chromatography (tablets); 5) high performance thin layer chromatography (HPTLC) (tablets); 6) capillary zone electrophoresis (tablets); 7) capillary electrochromatography; 8) micellar electrokinetic capillary chromatography (tablets); 9) UV – derivative spectrophotometry (tablets); 10) spectrofluorimetry (urine). From the results is obvious, that for determination of Losartan Potassium, HPLC is the most widely used method and spectrofluorimetry is specific for analysis in urine.

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