Abstract In current work were summarized the experimental results from the study of chemical stability of Galantamine peptide esters in different aqueous buffer solutions with pH = 2, pH = 7.4, pH = 9 at physiological temperature for 6 hours. The applied conditions were: stationary phase: silicagel G60F254; mobile phase: n – butanol : water = 30 : 10 v/v, reflectance – absorbance mode at λ = 282 nm.
Linear regression analysis was employed. The obtained regression equations show the proportional accordance between spot area and concentration.
The experimental results show that the examined Galantamine esters are resistant at physiological temperature to chemical hydrolysis in aqueous buffer solutions with pH = 2, pH = 7.4, pH = 9, which is proved by the fact that during 6 hour of experiment it is not observed the statistical significant difference between the values of area of spots.