Abstract

Theophylline-7-acetic acid (7-TAA) derivatives with several amino acids were screened for antiproliferative effects on acute (HL-60) and chronic (K-562) myeloid leukemia cells as well as on non-malignant cells derived from embryonic human kidney (HEK 293T). The anti-proliferative effects (IC₅₀) were revealed at relatively high concentrations, between 330.4 and 1051.9 μM, but the tested compounds proved to be devoid of cytotoxicity on HEK 293T in the evaluated concentration range (50-1200 μM). The amino acid esters demonstrated higher cytotoxicity towards the myeloid leukemia cells compared to the carboxylic acid derivatives.