Antimycobacterial activity of 4- and 3,4-substituted coumarins

personАвтори: G.Stavrakov, V. Angelova, V. Valcheva

Summary: The present article describes the evaluation of the in vitro activity against M. tuberculosis H37Rv of eight coumarin-derived aminoalcohols and amidoamines. Seven of the compounds display activity between 10 and 20 times higher than the classicall anti-TB drug ethambutol. The combination of aminoalcohol fragment on the 4th position and iminoalcohol fragment on the 3rd position of the coumarin scaffold enhances the activity.

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