Summary: The present article describes the evaluation of the in vitro activity against M. tuberculosis H37Rv of eight coumarin-derived aminoalcohols and amidoamines. Seven of the compounds display activity between 10 and 20 times higher than the classicall anti-TB drug ethambutol. The combination of aminoalcohol fragment on the 4^th position and iminoalcohol fragment on the 3^rd position of the coumarin scaffold enhances the activity.