Abstract.

The aim of this study was to investigate the possible influence of ivabradine and ω-3 polyunsaturated fatty acids for leukocyte’ and its populations counts in patients with ischemic heart failure. 357 patients with ischemic HF and sinus rhythm were observed. Additional usage of ω-3 PUFA caused of WBC count decrease for 12.3% – 12.5% (p<0.05) and neutrophil count for 8.3% – 9.6% (p<0.05). Thus, ω-3 polyunsaturated fatty acids have influence for elevated WBC (especially granulocytes) counts and showed their anti-inflammatory effects. Further studies designed to investigate the influence of these medications for other inflammatory markers in heart failure are needed to determine new approach in prediction and prevention of heart failure.