Abstract: This review article summarized the analytical methods for the quantitative determinations of H2 receptor antagonist famotidine by spectral methods, electrochemical procedures (potentiometric titration, polarography, diferential pulse voltammetry)as well as separation procedures such as high-performance liquid chromatography (HPLC), thin layer chromatography (HPTLC) and capillary electrophoresis. The clinical and pharmaceutical analysis of drug of interest required effective analytical procedures for quality control and therapeutic drug monitoring. An extensive survey of the literature published in various analytical and pharmaceutical chemistry-related journals has been presented in this review. The application of described methods for determination of famotidine in bulk, various pharmaceutical formulations and biological samples has also been discussed.