Synthesis of new derivatives of pyrrole tuberculostatics providing structural diversity

personАвтори: A. Bijev, S. Vladimirova

Abstract. Nine pyrrole-containing compounds were designed introducing reasonable structural novelties within the framework of the architecture of confirmed tuberculostatics. The new products were synthesized via adopted Paal-Knorr cyclization by condensation of three 1,4-dicarbonyl compounds with a set of substituted anilines, acting as primary amines. Preliminary In vitro tests have already registered encouraging anti-Mycobacterium tuberculosis activity

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