Efficient one-pot synthesis and evaluation of the cytotoxic activity of 2,4-dimethyl-1h-chromeno[4′,3′:4,5]pyrido[2,3-d]pyrimidine-1,3,7(2h,4h)-trione

personАвтори: G. Ts. Momekov, V.T. Angelova


A 2,4-dimethyl-1H-chromeno[4′,3′:4,5]pyrido[2,3-d]pyrimidine-1,3,7(2H,4H)-trione 3 was synthesized via a one-pot procedure. Itsstructure was established on the basis of FTIR, 1H NMR, 13C NMR,DEPT, COSY, HSQC, MS data and elemental analysis. The new compound was assayed for antiproliferative/cytotoxic effects in a panel of human tumor cell lines after 72 h exposure. MTT-dye reduction assay was used as a read-out system and IC50 as an end-point to evaluate efficacy. Our cytotoxicity screening indicates that the presented fused system exhibits moderate antiproliferative effect in a panel of human tumor cell lines of different origin and cellular type.

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