Abstract

The aim of this study was to investigate the in vitro effects of two groups of benzimidazoles on isolated rat hepatocytes. The first group had antihelminthic effect against Syphaciaobvelata andTrichinellaspiralis. From this group only КА-159 and КА-158 showed, compared with Albendazole, statistically significant lower cytotoxic effects on isolated rat hepatocytes. The second group, which was derivatives of Thiabendazole, was active only against Trichinella spiralis. From this group only KA-112 had lower cytotoxicity on isolated rat hepatocytes, compared to Albendazole. The differences in the toxic effects on isolated rat hepatocytes between benzimidazoles and Albendazole were connected with differences in their structures.