Abstract: Over the last few decades, an upward trend in the use of dietary suppplements has been observed worldwide. Accumulating information of risk associated with the use ofdietary supplementsis the main cause of increased scientific interest in these products. As opposite to medicines, thereare noregulatory requirements for preliminary data demonstrating the effectiveness and safety of dietary supplements. The legislation ofdietary supplements still has many weaknesses and it is in the process of development. Clarifying legislative and health problems associated with dietary supplements use is an important factor supporting their safe and rational use.