Abstract. There was radiology study of condition of vascular bed and bone tissue in patients with chronic arterial insufficiency who had combined therapy (by insulin and metformin)  and noninsulin therapy (by metformin or glimepiride or their combination). Direct connection  was established beween continued administration of insulin and cortex bone regeneration. Autors haven’t found an influence of metformin or glimepiride on bone tissue. Also thechanges of bone mineral density in toes and calcaneus were directly proportional to the aggravation of ischemic changes of diabetic foot.