Drug-related problems associated with use of statins in Ukraine: a hospital-based study

personАвтори: A. Zimenkovsky, K. Kostyana, O. Gorodnycha

Abstract.Statins are one of the most prescribed classes of cardiovascular drugs in the world of evidence for benefit. At the same time, lipid-lowering therapy by statins can be the cause of serious adverse reactions, such as myalgia, rhabdomyolysis, arrhythmias etc. Numerous drug-related problems (DRPs) can increase the potential risk of statin adverse reactions. In this retrospective study we analysed 21 medical records of patients admitted to the hospital with acute coronary syndrome in which were detected totally 479 DRPs. The study identified a high rate of inappropriate prescribing of statins because 4.8% (95% confidence interval: 3.1-7.1) of all DRPs were associated with use of these drugs. It was established that statins-induced DRPs were caused by drug-drug interactions (39.2%), excessive dosage(30.4%) and contraindicated use (30.4%). As a result, we formed 4 types of recommendations forreducing DRPs associated with use of statins in hospitalised patients with acute coronary syndrome.

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