Quercetin: an overview of biological effects and recent development of drug delivery systems

personАвтори: A. Zhelyazkova, D. Aluani, E. Georgieva, K. Yoncheva, V. Tzankova, Y. Yordanov

Abstract: The numerous beneficial pharmacological properties of quercetin justify its future clinical application. Nevertheless, the use of quercetin as a safe and effective therapeutic agent in the treatment of various diseases is limited because of the poor water solubility and membrane permeability, low bioavailability and instability. Several approaches have been undertaken to improve the bioavailability of quercetin, including the loading in different drug-delivery systems such as different types of micro and nanoparticles, nanocrystals, polymeric micelle, liposomes, microemulsionsect. This review summarizes the beneficial biological properties of quercetin, discusses the problems of its bioavailability and clinical use, and provides an overview of possible ways to overcome these problems by its loading in the perspective drug-delivery systems.

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