Abstract

In the review we systematize the theoretical and experimental data concerning methods of condensed thiazoloquinazolines synthesis, with respect to compile the literature on synthetic approaches utilized for thiazolo[2,3-b]quinazolines, thiazolo[4,3-b]quinazolines, thiazolo[3,2-a]quinazolines, thiazolo[3,4-a]quinazolines, and thiazolo[5,4-f]quinazolines construction. This paper also reviews the current knowledge with regard of prospects and challenges of condensed thiazoloquinazolines use in the targeted synthesis of biologically active substances and analysis of recent advances in this heterocyclic compounds pharmacology screening. Generalization of the published data gives reason to consider thiazoloquinazolines scaffold as an important pharmacophore in compounds which are characterized with diverse biological activity.