Effect of 4-aminopyridine derivatives with a peptide moiety on scopolamine-induced memory impairment in mice

personАвтори: I. Kostadinova, I. Nikolova, L. Vezenkov, N. Danchev, Tch. Ivanov


Alzheimer’s disease (AD) is a progressive neurodegenerative disease affecting learning and memory processes. The most commonly used drugs for symptomatic treatment of AD are the inhibitors of the enzyme acetylcholinesterase (AChE) – Galantamine,Rivastigmine, Donepezil. The aim of this study is to investigatethe effects on locomotor activity and passive avoidance after single and repeated administration of the compounds in mice. The results demonstrate that newly synthesized compounds that arehybrid compounds including 4-aminopyridine and also modified dipeptides holding the residue of the N-(3, 4-dichlorophenyl)-D,L-Ala-OH, decrease the locomotor activity of mice at doses representing 1/20 of LD50 of the respective substances.  The memory improving potential of the compounds was examined using thepassive avoidance test and for deterioration of memory processes was used scopolamine in dose 3 mg/kg. The results indicate that some of the compounds antagonize the effects of scopolamine after singleandrepeatedadministration.Tch. Ivanov

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