Summary:

A technologicaloptimization of production process for manufacture of diclofenac sodium gastro-resistant tablets was explored. Tableting after granulation in fluidized bed conditions wereexamined as possible simplified methods for preparation of diclofenac-containing tablets. Single and double-layer enteric coating were proposed as suitable and less time consumable method for preparation of entero-solvent coating. Voltaren 50 mg was used as a reference drug product for evaluation of the factor of similarity.