Aryltetralin lignans from in vitro cultures of Linum elegans and their cytotoxic activity

personАвтори: G. Momekov, I. Antonova, I. Ionkova


In continuation of our research on lignans in Bulgarian Linum species, for the first time we have established several callus and suspension cultures from single sterile seedlings from L. elegans, endemic species in the Balkan area and checked for the occurrence of lignans. Here we report the identification of the 6-methoxypodophyllotoxin (MPTOX) as the main lignan in the callus and suspension from this endemic plant species belonging to the section Syllinum. The content of MPTOX is 1.9 mg/g dry weight. The extracts showed moderate cytotoxic activity on human malignant cell lines K-562, LAMA-84, HD-MY-Z and EJ compared with etoposide as a positive control.

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