Hormone-dependent differences in drug metabolism

personАвтори: M. Mitcheva, R. Simeonova, V. Vitcheva


This review discusses some sex differences in drug metabolism in experimental animals and humans. The growth hormone, sex hormones and other factors exert principal influence on drug metabolism. In rats and mice, sex-dependent differences in circulating growth hormone profiles are responsible for the differential expression of sex-dependent isoforms of cytochrome P450 which is the basis for the sexual dimorphism in drug metabolism both in experimental animals and human.

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