Preparation of amino-pegylated poly(anhydride) nanoparticles applying solvent displacement method

personАвтори: J. M. Irache, K. Yonchev


Simple solvent displacement technique was applied for the preparation of aminopegylated poly(methyl vinyl ether-co-maleic anhydride) nanoparticles (PVM/MA-NP). Two amino-functionalized polyethylene glycols were selected, in particular bis-aminoethyl polyethylene glycol (DAE-PEG) and bis-aminopropyl polypropylene glycol–polyethylene glycol-polypropylene glycol (DAP-PEG). Higher pegylation degree was achieved with DAE-PEG probably due to the higher capacity of its amino-groups to interact with the anhydride groups of PVM/MA copolymer. Further, the increasing of the initial concentration of both PEGs increased pegylation degree. However, the higher association of PEGs reflected in larger nanoparticle size and higher polydispersity. Hence, appropriate adjustment of initial concentration of DAE-PEG and DAP-PEG is needed for the achievement of nanoparticles with optimal physico-chemical properties.

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